Toxicol 24, 34 Hjortkjaer,R. Sarlo; B. None of the oral toxicity studies performed by members of the consortium in the past 40 years, as well as published data from other studies revealed any effect that indicates that enzymes could have an adverse effect on the reproduction system in males or females.

Exposure to enzymes will be limited because of the DMEL derived minimum exposure levels settings for workers, professionals and consumers to prevent respiratory allergy supported by exposure scenarios and DMEL values ref.

Procedura de insertie a unui implant depinde de anumiti factori : stare generala de sanatate, oferta osoasa, disponibilitatea pacientului. In cazul in care pacientul prezinta o rezorbtie osoasa importanta, datorat intervalului lung de timp de la data extractiei cativa ani pana la inserara implantului, este posibil sa necesite operatiuni suplimentare, precum sinus lifting inaltarea membranei sinusale si aditie de os pentru a favoriza viabilitatea implantului in timp. Limitele principale care asigura succesul unui implant dentar sunt date de cantitatea si calitatea osului in care se va insera implantulpozitia sinusului maxilar la arcada superioara sau a canalului principal cu vase si nervi pentru mandibula. Contraindicatiile principale pentru implantologie sunt boli sistemice precum diabetulhepatita, dezechilibre ale sistemului circulator si osos dar si factori locali de exemplu: dimensiuni insuficiente-inaltime si grosime-ale osului unde ar fi necesara amplasarea implantului.

Apart from the irritation potential of some proteases, respiratory allergy is generally considered to be the only human health hazard of enzymes indicating that this is the most sensitive endpoint considering enzyme toxicity. Concentrations that are not expected to result in respiratory allergy will certainly not result in any other toxic effect ref.

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This conclusion is substantiated by the material that follows. Although endocrine disrupting chemicals are a broad group of chemicals consisting of man-made and natural compounds it is unlikely that enzymes have the potential to cause endocrine disruption.

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The enzymatic structure is different from any endocrine disrupter known to date ref 1. Due to the high biodegradability of enzymes, it is highly unlikely that they could reach target organs or sites to any significant amount or of any significant period of time. Testing of enzymes in currently available screening assays typically based on hormone receptor binding cannot be expected to provide any evidence for endocrine disruption due to the specific features of enzymes.

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Data from acute and subchronic oral toxicity studies provide evidence that enzymes are of very low toxicological activity ref. None of the oral toxicity studies performed by members of the consortium in the past 40 years, as well as published data from other studies revealed any effect that indicates that enzymes could have an adverse effect on the reproduction system in males or females.

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Both proteolytic and non-proteolytic enzymes have been investigated for their teratogenic and reproductive toxicity potential. Several of these studies have been published in peer reviewed articles ref.

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Enzymes have been produced and used for many years without any evidence for reproductive potential in humans. Considering that endocrine disrupting chemicals in general are a factor of less potent than physiologically relevant hormones ref. Furthermore, enzymes have been used for decades to treat pancreatic insufficiency in both children and adults without any evidence of reproductive toxicity ref.

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In conclusion, toxicokinetic data together with the enzymatic structure and the weight of evidence from animal studies and human exposure provide no evidence for reproductive toxicity of enzymes.

References 1 Whaley,D. Environmental Health Perspectives3 Laake,K. Genetics in Medicine 3, 4 Amalfitano,A. Genetics in Medicine 3, 5 Andersen,J. Journal of Food Protection 50, 6 Ankel,E. In Vitro 20, 7 Ashby,R.

The structure of an inhibitor of cholesterol biosynthesis isolated from barley.

Toxicology Letters Shannon 36, 8 Bar,A. Food additives and contaminants 14, 10 Biziulevichius,G. Veterinary research 28, 11 Brinch,D.

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Food additives and contaminants 19, 13 Broadmeadow,A. Food additives and contaminants 11, 14 Broadwell,A. Journal of bacteriology15 Bui,Q. International Alpha dating site israel of Toxicology 23, 16 Baer,A.

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Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 33, 17 Cerven,D. Regulatory Toxicology and Pharmacology 51, 18 Ciofalo,V.

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Regulatory Toxicology and Pharmacology 37, 19 Coenen,T. Food and chemical toxicology : an cam dating app journal published for the British Industrial Biological Research Association 33, 20 Coenen,T.

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Food and chemical toxicology : an international journal published for the British Industrial Biological Research Norwich dating online 35, 21 Coenen,T. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 36, 22 Coenen,T. Food and chemical toxicology alpha dating site israel an international journal published for the British Industrial Biological Research Association 38, 23 Cook,M.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 41, 24 Deboer,A. Journal of Food Protection 56, 25 Durden,D. International Journal of Cancer 27, 26 Elvig,S.

'Tocol-omic' diversity in wild barley, short communication.

Regulatory Toxicology and Pharmacology 37, 27 Gao,C. Asian Journal of Ecotoxicology 2, 28 Gao,F.

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British Poultry Science 48, 29 Greenough,R. Food Chem. Toxicol 29, 30 Greenough,R.

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